Wortmannin

Wortmannin is a fungal metabolite that irreversibly inhibits phosphatidylinositol 3-kinase (PI3K), a key regulator of intracellular signaling pathways involved in growth, metabolism, and autophagy. In neuroscience, Wortmannin is used to investigate the PI3K/Akt/mTOR pathway, which plays a central role in neuronal survival, synaptic plasticity, and neuroinflammation. By inhibiting PI3K, Wortmannin suppresses autophagy and disrupts membrane trafficking—processes essential for neuronal maintenance and function. Its application in neurodegenerative disease models helps elucidate the impact of impaired PI3K signaling on protein aggregation, mitochondrial dysfunction, and cell death. Wortmannin is also used to study insulin signaling in the brain, relevant to Alzheimer’s disease and metabolic-cognitive disorders.

Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, Highly toxic by skin absorption

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H300 + H310- Fatal if swallowed or in contact with skin
• H330- Fatal if inhaled.

Precautionary statements:

• P260- Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
• P264- Wash hands thoroughly after handling.
• P280- Wear protective gloves/ protective clothing.
• P284- Wear respiratory protection.
• P302 + P350- IF ON SKIN: Gently wash with plenty of soap and water.
• P310- Immediately call a POISON CENTER or doctor/ physician.

Wortmannin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-392)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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