Liver Cancer Cell Lines

Validated human liver cancer cell lines — HepG2, HuH7, Hep3B, PLC/PRF/5, SK-HEP-1 and the SNU series — for hepatocellular carcinoma, viral hepatitis, drug metabolism and hepatotoxicity research.

19Products
19 products
Image ProductProduct Type ApplicationPrice Status ACTION
CRISPRa (SAM) HepG2 Cell Line – Figure 1 of 1
Research Validated
CRISPR KO Cell Line Cell Culture (Growth), Hepatotoxicity Assay, Drug Metabolism Studies
$2,500.00
Regular price $2,500.00
In Stock at Manufacturer
ARE Luciferase Reporter HepG2 Cell Line (Nrf2 Antioxidant Pathway) – Figure 1 of 2
Research Validated
Reporter Cell Line Cell Culture (Growth), Reporter Assay, Hepatotoxicity Assay, Drug Metabolism Studies
$2,825.00
Regular price $2,825.00
In Stock at Manufacturer
SNU-878 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$550.00
Regular price $550.00
In Stock
SNU-449 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$550.00
Regular price $550.00
In Stock
SNU-398 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$550.00
Regular price $550.00
In Stock
SNU-387 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$550.00
Regular price $550.00
In Stock
SNU-182 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$395.00
Regular price $395.00
In Stock
SK-HEP-1 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$395.00
Regular price $395.00
In Stock
RBE cell
Best Seller Bulk Pricing
Cell Culture (Growth), Functional Assay
$550.00
Regular price $550.00
In Stock
PLC/PRF/5 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$395.00
Regular price $395.00
In Stock
Mahlavu cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$395.00
Regular price $395.00
In Stock
Li-7 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$650.00
Regular price $650.00
In Stock
HuH7 cell
Best Seller Featured Bulk Pricing
Cell Culture (Growth), Functional Assay
$395.00
Regular price $395.00
In Stock
HuH-6 cell
Best Seller Featured Bulk Pricing
Cell Culture (Growth), Functional Assay
$395.00
Regular price $395.00
In Stock
HuCC-T1 cell
Best Seller Featured Bulk Pricing
Cell Culture (Growth), Functional Assay
$800.00
Regular price $800.00
In Stock
HROHep03 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$800.00
Regular price $800.00
In Stock
HROC395Met1 cell
Bulk Pricing
Cell Culture (Growth), Functional Assay
$800.00
Regular price $800.00
In Stock
HepG2 cell
Best Seller Featured Bulk Pricing
Cell Culture (Growth), Hepatotoxicity Assay, Drug Metabolism Studies
$395.00
Regular price $395.00
In Stock
HEP3B cell
Best Seller Featured Bulk Pricing
Cell Culture (Growth), Immunophenotyping, Flow Cytometry
$395.00
Regular price $395.00
In Stock

About Liver Cancer Cell Lines

Liver cancer cell lines are immortalized human cultures derived from hepatocellular carcinoma (HCC), hepatoblastoma and cholangiocarcinoma tumors. They are the workhorse in vitro models for studying liver tumor biology, viral hepatitis, drug metabolism and hepatotoxicity, giving researchers a reproducible, scalable alternative to scarce primary human hepatocytes. This collection brings together validated human liver cancer lines — including HepG2, HuH7, Hep3B, PLC/PRF/5, SK-HEP-1 and the SNU series — plus engineered reporter derivatives.

Choosing a liver cancer cell line: HepG2 vs HuH7 vs Hep3B

The three most widely used human lines serve different jobs. Match the model to your mechanism.

FeatureHepG2HuH7Hep3B
Tumor originHepatoblastomaHepatocellular carcinomaHepatocellular carcinoma
Hepatitis virusHBV studies; not HCVPermissive to HCVIntegrated HBV genome; expresses HBsAg
Metabolic functionStrong hepatocyte-like (albumin, urea; low CYP)Moderate; albumin, AFPProduces AFP & plasma proteins
TumorigenicityNon-tumorigenicTumorigenicTumorigenic
Best forDrug metabolism & hepatotoxicityHCV / antiviral & HCC signalingHBV biology & p53-null studies
How to read this: choose HepG2 for metabolism and toxicity screening, HuH7 when the biology depends on HCV replication, and Hep3B for HBV-integrated, p53-deficient contexts. Many programs run two lines in parallel to separate virus-specific effects from general hepatocyte biology. See our full HuH7 vs HepG2 application note for details.

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