Nanodisc Membrane Proteins

Recombinant membrane proteins reconstituted in nanodiscs — a native-like lipid bilayer environment for functional, cryo-EM and binding studies.

Membrane proteinsNative lipid bilayerCryo-EM readyGPCRs & transporters

Other formats: Detergent micelle · VLP

Nanodisc: a membrane scaffold protein nanodisc placing the target protein in a native lipid bilayer

908 products

Product	Product Type	Application	Price	Status	ACTION
New Human GPR17-Strep full length protein-synthetic nanodisc Target: GPR17	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR25-Strep full length protein-synthetic nanodisc Target: GPR25	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPRC5C-Strep full length protein-synthetic nanodisc Target: GPRC5C	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP173-Strep full length protein-synthetic nanodisc Target: GP173	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP176-Strep full length protein-synthetic nanodisc Target: GP176	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR26-Strep full length protein-synthetic nanodisc Target: GPR26	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP148-Strep full length protein-synthetic nanodisc Target: GP148	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP141-Strep full length protein-synthetic nanodisc Target: GP141	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR151-Strep full length protein-synthetic nanodisc Target: GPR151	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR158-Strep full length protein-synthetic nanodisc Target: GPR158	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP139-Strep full length protein-synthetic nanodisc Target: GP139	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP156-Strep full length protein-synthetic nanodisc Target: GP156	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPRC6A-Strep full length protein-synthetic nanodisc Target: GPRC6A	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP149-Strep full length protein-synthetic nanodisc Target: GP149	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GP146-Strep full length protein-synthetic nanodisc Target: GP146	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR143-Strep full length protein-synthetic nanodisc Target: GPR143	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR157-Strep full length protein-synthetic nanodisc Target: GPR157	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR119-Strep full length protein-synthetic nanodisc Target: GPR119	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR84-Strep full length protein-synthetic nanodisc Target: GPR84	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GRM2-Strep full length protein-synthetic nanodisc Target: GRM2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GRM7-Strep full length protein-synthetic nanodisc Target: GRM7	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR20-Strep full length protein-synthetic nanodisc Target: GPR20	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR132-Strep full length protein-synthetic nanodisc Target: GPR132	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR65-Strep full length protein-synthetic nanodisc Target: GPR65	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR55-Strep full length protein-synthetic nanodisc Target: GPR55	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR87-Strep full length protein-synthetic nanodisc Target: GPR87	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR75-Strep full length protein-synthetic nanodisc Target: GPR75	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPRC5D-Strep full length protein-synthetic nanodisc Target: GPRC5D	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $810.00 Regular price From $810.00	In Stock at Manufacturer	View
New Human GPR39 full length protein-synthetic nanodisc Target: GPR39	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human GPR21 full length protein-synthetic nanodisc Target: GPR21	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human GRM2 full length protein-synthetic nanodisc Target: GRM2	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human GRM7 full length protein-synthetic nanodisc Target: GRM7	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human GPR84 full length protein-synthetic nanodisc Target: GPR84	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human GPR20 full length protein-synthetic nanodisc Target: GPR20	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human GPR132 full length protein-synthetic nanodisc Target: GPR132	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View
New Human GPR65 full length protein-synthetic nanodisc Target: GPR65	Transmembrane Protein	Functional Assay (In Vitro) ELISA	From $900.00 Regular price From $900.00	In Stock at Manufacturer	View

About Nanodisc Membrane Proteins

Nanodiscs wrap a single membrane protein in a small disc of native lipid bilayer held by two membrane scaffold proteins, keeping the target water-soluble while preserving a near-native lipid environment. This collection lists recombinant membrane proteins supplied pre-reconstituted in nanodiscs.

Choosing a membrane-protein format: Nanodisc vs Detergent vs VLP

Every product here is supplied in a nanodisc. Here is how that choice compares with the two other formats we stock, so you can confirm it fits your experiment.

Consideration	Nanodisc	Detergent micelle	VLP
Lipid environment	Native lipid bilayer disc	Detergent shell (lipids removed)	Native membrane on a capsid
Native function preserved	High	Variable — often reduced for GPCRs	High (keeps oligomeric state)
Best structural method	Single-particle cryo-EM	X-ray crystallography / LCP	Not for high-resolution structure
Display / valency	Monomeric, defined stoichiometry	Monomeric	Multivalent — many copies per particle
Typical particle	~9–13 nm disc	Protein–detergent micelle	~100 nm engineered capsid
Best for	Function + cryo-EM, SPR / BLI binding	Broad selection, high-res X-ray, cost	Immunization, antibody discovery, vaccines
Watch-outs	Disc size caps very large complexes	May alter GPCR conformation / stability	Less suited to atomic-resolution structure

How to read this: if you need the protein to behave as it does in a cell — ligand binding, channel gating, GPCR pharmacology — and you are heading toward cryo-EM, the nanodisc format is usually the right starting point. Choose detergent when you need the broadest selection or high-resolution X-ray, and VLPs when multivalent, native-oligomeric display matters (for example, raising antibodies).