4ICD|Avian erythroblastic leukemia viral oncogene homolog 4|Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4|E4ICD|EC 18.104.22.168|ErbB4|ERBB4 intracellular domain|ERBB4|HER 4|HER4|Mer4|MGC138404|Oncogene ERBB4|P180erbB4|Proto-oncogene-like protein c-ErbB-4|Receptor protein tyrosine kinase erbB 4 precursor|Receptor tyrosine protein kinase erbB 4|s80HER4|Tyrosine kinase type cell surface receptor HER4|Tyrosine kinase-type cell surface receptor HER4|v erb a avi
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
Homo Sapiens (Human)
Synthetic peptide, corresponding to amino acids 1246-1310 of Human ErbB-4.
Human, Mouse, Rat
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: ErbB-4 (E1280) polyclonal antibody detects endogenous levels of ErbB-4 protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.