Forkhead box protein O4|Fork head domain transcription factor AFX1|AFX|AFX1|MLLT7|FOXO4|Forkhead box protein O1|Forkhead box protein O1A|Forkhead in rhabdomyosarcoma|FOXO1|FKHR|FOXO1A|Forkhead box protein O3|AF6q21 protein|Forkhead in rhabdomyosarcoma-like 1|FOXO3|FKHRL1|FOXO3A
FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors.FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Synthetic peptide, corresponding to the RPRSCTWPL of Human FoxO1.
Human, Mouse, Rat
70 to 82 kDa
Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: FoxO1/3/4 (P18) polyclonal antibody detects endogenous levels of FOXO1/3/4 protein.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.