| Field | Specification |
|---|---|
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
UNC3474 (CAS 1648707-79-2) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 1648707-79-2 |
|---|---|
| Molecular Formula | C17H28N2O |
| Molecular Weight | 276.42 g/mol |
| SMILES | O=C(NCCCNC(C)(C)C)C1=CC=CC(=C1)C(C)C |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.0±0.3 uM. It impedes 53BP1's recruitment to DNA double-strand breaks (DSBs), maintaining the protein's autoinhibited state within cells (1).
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner rather than a high-intensity ultrasonic disruptor. Bath sonicators provide gentle, uniform agitation appropriate for dissolving solid compounds without generating cavitation damage or excessive heat. Ensure the solvent tube is fully submerged and use short sonication pulses of 5–10 seconds.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
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- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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