Trolox

Trolox is a water-soluble analog of vitamin E (α-tocopherol) with potent antioxidant properties. In neurodegenerative disease research, Trolox is widely used to study oxidative stress, a key contributor to neuronal damage in conditions such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Trolox scavenges reactive oxygen species (ROS) and protects against lipid peroxidation, mitochondrial dysfunction, and DNA damage. Its ability to cross cell membranes and neutralize oxidative insults makes it a valuable tool for evaluating neuroprotective strategies and antioxidant therapies in both in vitro and in vivo models of neurodegeneration.

WHMIS Classification: D2B Toxic Material Causing Other Toxic Effects. Moderate skin irritant. Moderate respiratory irritant. Moderate eye irritant.

GHS Classification

Acute toxicity, Oral (Category 5)

Skin corrosion/irritation (Category 2)

Serious eye damage/eye irritation (Category 2A)

Specific target organ toxicity - single exposure (Category 3), Respiratory system

Signal word:

Warning

Hazard statement(s):

• H303 May be harmful if swallowed.
• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.

Precautionary statement(s):

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Health hazard:

2

Flammability:

0

Physical hazards:

0

Potential Health Effects: Inhalation - May be harmful if inhaled. May cause respiratory tract irritation.

Skin - May be harmful if absorbed through skin. May cause skin irritation.

Eyes - May cause eye irritation.

Ingestion - May be harmful if swallowed.

Trolox (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-556)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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