| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-deoxymannojirimycin, 1-DEOXYNOJIRIMYCIN, 19130-96-2, DUVOGLUSTAT, (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, Moranoline, Deoxynojirimycin |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in water (25 mg/ml) |
| Source | Synthetic |
| Storage |
1-Deoxynojirimycin (DNJ) is a naturally occurring iminosugar best known for its potent inhibition of α-glucosidases, enzymes critical to glycoprotein processing and carbohydrate metabolism. While DNJ has been extensively studied in the context of metabolic disorders such as diabetes and lysosomal storage diseases, its relevance to neuroscience is gaining attention. In neurodegenerative disease research, DNJ’s ability to modulate glycosphingolipid metabolism positions it as a promising candidate for targeting pathological protein aggregation and lysosomal dysfunction—hallmarks of disorders like Parkinson’s and Gaucher disease. Recent studies suggest that DNJ and its derivatives may influence neuroinflammatory pathways and neuronal survival by altering glycan processing, potentially mitigating neurodegeneration. Its role in modulating endoplasmic reticulum stress and autophagy further underscores its therapeutic potential in neurodegenerative contexts. Additionally, DNJ’s capacity to cross the blood-brain barrier enhances its appeal for central nervous system applications. Beyond neuroscience, DNJ remains a cornerstone compound in glycobiology and antiviral research, particularly for its ability to interfere with viral glycoprotein maturation.
WHMIS Classification: Not Rated. Not a hazardous substance or mixture.
Health hazard:
0
Flammability:
0
Physical hazards:
0
Potential Health Effects: Inhalation - May be harmful if inhaled. May cause respiratory tract irritation.
Skin - May be harmful if absorbed through skin. May cause skin irritation.
Eyes - May cause eye irritation.
Ingestion - May be harmful if swallowed.
1-Deoxynojirimycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-547)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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