| Field | Specification |
|---|---|
| Alternative names | PLPC |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C42H80NO8P |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC, also known as PLPC, is a phosphatidylcholine phospholipid. It and its oxidized derivatives serve as models for studying lipid peroxidation, membrane structure, and phospholipase A2 activity, and the compound can be applied in research on atherosclerosis, oxidative stress, and the properties of lipid bilayers[1][2][3]. It is supplied as a colorless to light yellow liquid (C42H80NO8P, MW 758.06) at 99.0% purity.
Physical & Chemical Properties
| CAS Number | 17708-90-6 |
|---|---|
| Molecular Formula | C42H80NO8P |
| Molecular Weight | 758.06 g/mol |
| Purity | 99.0% |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| SMILES | CCCCC/C=C\C/C=C\CCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Solution, -20°C, 2 years. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
After 20 min hydration, 30 min vacuum drying, and 30 min centrifugation, 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC (PLPC) shows the characteristic acyl chain order of a fluid membrane and a baseline H2-bonded nitroxide population of 28% in the central region of the bilayer, with an Azz polarity parameter of 3.28 mT[1]. No change in polarity/proticity of the sub-headgroup region at cryogenic temperatures is seen with 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC, while the central region of the bilayer holds a 28% H-bonded nitroxide population[1]. In human LDL, 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC (0.75 mg/mL LDL; 0.5-7 h) undergoes free radical oxidation, with time-dependent formation of PLPC hydroperoxides and alcohols and nearly 15% of endogenous PLPC oxidized after 7 h; inhibition of PLPC oxidation in the LDL surface layer is less effective with α-tocopherol[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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