| Field | Specification |
|---|---|
| Alternative names | 1-P-GPA |
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite |
| Molecular weight | |
| Molecular formula | C19H39O7P |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
1-Palmitoyl-sn-glycerol 3-phosphate, also known as 1-P-GPA, is a phospholipid and lipid membrane precursor. It integrates into POPC liposomes and causes significant changes in membrane curvature, and it induces platelet aggregation, although its activity is 30-fold lower than that of 1-hexadecyl-sn-glyceryl-3-phosphate[1][2]. It is supplied as a white to off-white solid (C19H39O7P, MW 410.48) at 98.3% purity.
Physical & Chemical Properties
| CAS Number | 7220-34-0 |
|---|---|
| Molecular Formula | C19H39O7P |
| Molecular Weight | 410.48 g/mol |
| Purity | 98.3% |
| Appearance | Solid |
| Color | White to off-white |
| Structure Classification | Others |
| SMILES | O=P(O)(O)OC[C@H](O)COC(CCCCCCCCCCCCCCC)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Initial Source | Endogenous metabolite |
| Solubility | In Vitro: DMSO: 2.5 mg/mL (6.09 mM; Requires sonication and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 2.5 mg/mL (6.09 mM) | requires sonication and warming; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Platelet suspensions aggregate in response to 1-Palmitoyl-sn-glycerol 3-phosphate, with a half-maximal effective concentration (EC50) of 290 nM[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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