| Field | Specification |
|---|---|
| Alternative names | SLPC; 18:0-18:2 PC |
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite |
| Molecular weight | |
| Molecular formula | C44H84NO8P |
| Purity | |
| SMILES | |
| Form | Oil |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, also known as SLPC and 18:0-18:2 PC, is an endogenous phospholipid marker in the glycerophospholipid metabolic pathway and a core component of the phospholipid bilayer of cell membranes and high-density lipoprotein (HDL), where it helps regulate lipoprotein functional homeostasis and can serve as a key lipid responsive to radiation injury and cardiometabolic disease. Its level decreases in a dose-dependent manner in mouse serum as ionizing radiation dose increases and decreases significantly in human HDL in metabolic syndrome, so it can serve as a biological dosimeter for rapid, accurate assessment of radiation absorbed dose in exposed individuals and as a lipidomics research target for cardiometabolic diseases such as lipid metabolic syndrome and early-onset coronary heart disease[1][2]. It is supplied as a colorless to light yellow oil (C44H84NO8P, MW 786.11) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 27098-24-4 |
|---|---|
| Molecular Formula | C44H84NO8P |
| Molecular Weight | 786.11 g/mol |
| Purity | 98.0% |
| Appearance | Oil |
| Color | Colorless to light yellow |
| Structure Classification | Lipids |
| SMILES | CCCCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Initial Source | Endogenous metabolite |
| Solubility | In Vitro: DMSO: 100 mg/mL (127.21 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Paavola T, Bergmann U, Kuusisto S, et al. Distinct fatty acid compositions of hdl phospholipids are characteristic of metabolic syndrome and premature coronary heart disease—Family study[J]. International Journal of Molecular Sciences, 2021, 22(9): 4908.
[2]. Huang J, Wang Q, Qi Z, et al. Lipidomic profiling for serum biomarkers in mice exposed to ionizing radiation[J]. Dose-Response, 2020, 18(2): 1559325820914209.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (127.21 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
In mouse serum lipidomics LC-MS assays, 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine (endogenous relative quantitative concentration in mouse serum, measured by ex vivo serum treatment 6 h after ionizing radiation exposure) is identified as an ionizing radiation-responsive lipid. Its serum abundance falls significantly as 60Co source γ-ray doses increase across 0-8 Gy, and it correlates strongly and negatively, in a linear manner, with radiation dose[2]. In mouse serum lipidomics LC-MS assays, 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine (endogenous relative quantitative concentration in mouse serum, measured by ex vivo serum treatment 72 h following ionizing radiation exposure) displays a significant dose-dependent decrease in serum abundance across 60Co source γ-ray irradiation doses of 0-8 Gy, together with a strong linear negative correlation with radiation dose[2]. In human HDL lipidomics LC-MS detection experiments, the level of 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine in the HDL3 subfraction is 15% lower in subjects with metabolic syndrome than in non-diseased subjects[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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