| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H34O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid. Its formation increases under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. It can serve as a single biomarker differentiating NAFL (non-alcoholic fatty liver disease) from NASH (non-alcoholic steatohepatitis), and it can be used in studies on preterm birth, autism, and pulmonary hypertension[1][2][3][4][5].
It has the molecular formula C20H34O4, MW 338.48.
Physical & Chemical Properties
| CAS Number | 192461-95-3 |
|---|---|
| Molecular Formula | C20H34O4 |
| Molecular Weight | 338.48 g/mol |
| SMILES | CCCCC/C=C\CC(O)C(O)C/C=C\C/C=C\CCCC(O)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Levels of 11,12-DiHETrE decrease following sEH inhibitor administration, so it can act as a pharmacodynamic biomarker for soluble epoxide hydrolase (sEH) inhibitors[1]. Plasma 11,12-DiHETrE concentrations are significantly higher in patients with non-alcoholic steatohepatitis (NASH) than in patients with non-alcoholic fatty liver (NAFL) and healthy controls[2]. A significant positive correlation exists between 11,12-DiHETrE and the presence of resting pulmonary arterial hypertension[3]. Individuals with higher 11,12-DiHETrE exposure in umbilical cord blood are more likely to present with severe autism spectrum disorder (ASD) symptoms[4]. Elevated 11,12-DiHETrE levels reflect an imbalance in the pro-resolving/anti-inflammatory pathway[5].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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