| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid, SWO2 |
| Form | White solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (20 mg/ml) |
| Source | Synthetic |
| Storage |
115-7C is a small molecule that activates the ATPase activity of Hsp70 and promotes substrate refolding. It binds to the IIA subdomain of DnaK and enhances the formation of the DnaK-DnaJ complex. In neurodegenerative disease research, 115-7C is of interest for its role in maintaining proteostasis and preventing protein aggregation. By stimulating Hsp70’s chaperone activity, 115-7C may help mitigate the accumulation of misfolded proteins such as tau and alpha-synuclein, which are central to the pathology of Alzheimer’s and Parkinson’s diseases.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
115-7C (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-123)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Jinwal et al. (2009) J.Neurosci. 29:12079.
3. Chafekar et al. (2012) ACS Chem Biol. 7:1556.
4. Walter et al. (2011) J. Biol. Chem. 286:40486
