| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C36H68O4 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
12-OAHSA is a component of olive oil. It has oral activity and improves glucose homeostasis in insulin-resistant obese mice[1]. It is supplied as a colorless to light yellow liquid (C36H68O4, MW 564.92) at 99.0% purity.
Physical & Chemical Properties
| CAS Number | 101901-73-9 |
|---|---|
| Molecular Formula | C36H68O4 |
| Molecular Weight | 564.92 g/mol |
| Purity | 99.0% |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| SMILES | CCCCCCCC/C=C\CCCCCCCC(OC(CCCCCC)CCCCCCCCCCC(O)=O)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Solution, -20°C, 2 years. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
12-OAHSA (25 μM, 24 h) suppresses LPS-induced IL-1b, IL-6, Nos2, and Tnf-α in Raw 264.7 macrophages[1]. In Raw 264.7 macrophages, 12-OAHSA (25 μM, 6 h) decreases IKKβ phosphorylation while increasing p65 phosphorylation[1].
In Vivo
In HFD induced obese C57BL/6 mice, 12-OAHSA (30 mg/kg, p.o., for 10 d) inhibits obesity-induced insulin resistance[1].
| Animal Model | 10-week HFD induced obese C57BL/6 mice[1] |
|---|---|
| Dosage | 30 mg/kg |
| Administration | p.o., for 10 d |
| Result | Decreased adipose tissue macrophage (ATMs), and CD4+ and CD8+ T lymphocytes in eWAT. Inhibits obesity-induced adipose tissue inflammation. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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