| Field | Specification |
|---|---|
| Alternative names | Azido Palmitic Acid |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C15H29N3O2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
15-Azido-pentadecanoic acid, also known as Azido Palmitic Acid, is a click chemistry reagent bearing an azide group. It can be used to identify and characterize post-translationally palmitoylated proteins through a simple, robust two-step labeling and detection technique[1]. The azide group allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules bearing DBCO or BCN groups. It is supplied as a white to off-white solid (C15H29N3O2, MW 283.41) at 99.88% purity.
Physical & Chemical Properties
| CAS Number | 118162-46-2 |
|---|---|
| Molecular Formula | C15H29N3O2 |
| Molecular Weight | 283.41 g/mol |
| Purity | 99.88% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | [N-]=[N+]=NCCCCCCCCCCCCCCC(O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Solubility | In Vitro: DMSO: 100 mg/mL (352.85 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (352.85 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Click chemistry refers to selective, modular, wide-ranging, high-yield chemical reactions that enable rapid synthesis of new compounds by linking heteroatoms (C-X-C). Bertozzi extended click chemistry into a new dimension, bioorthogonal chemistry, which is defined as a rapid and selective reaction that leaves biological processes undisturbed under physiological conditions. Common reaction structures used in click chemistry include Azide, Alkyne, DBCO, BCN, TCO and Tetrazine.
Data provided by the manufacturer.
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Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. Nat Cancer 2025 May;6(5):768-785. PMID: 40108413
Extracellular Vesicle-Transferred ATP-Citrate Lyase Induces Monocyte Differentiation Toward Tumor-Associated Macrophages and Fuels Hepatocellular Carcinoma Progression. Adv Sci (Weinh) 2026 Jun;13(35):e21458. PMID: 41995119
Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE. Cell Death Dis 2025 Jan 14;16(1):17. PMID: 39809787
