| Field | Specification |
|---|---|
| Alternative names | 15-Deoxy-Δ12,14-PGD2 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H30O4 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2, is an agonist of the prostaglandin receptor DP2. It binds DP2 with a Ki of 50 nM and induces eosinophil activation with an EC50 of 8 nM, and it stimulates recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), driving PPARγ-mediated transcription. It is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 μg/mL) and inhibits ADP-induced platelet aggregation (IC50 = 320 ng/mL). It is supplied as a colorless to light yellow liquid (C20H30O4, MW 334.45) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 85235-11-6 |
|---|---|
| Molecular Formula | C20H30O4 |
| Molecular Weight | 334.45 g/mol |
| Purity | 98.0% |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| SMILES | O=C1/C([C@H]([C@H](C1)O)C/C=C\CCCC(O)=O)=C/C=C/CCCCC |
| Signaling Pathway | Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor; Cell Cycle/DNA Damage; GPCR/G Protein; Protein Tyrosine Kinase/RTK |
| Storage | Solution, -20°C, 2 years. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Bundy, et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J. Med. Chem. 26(6), 790-799 (1983).
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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