17-AAG

Product details

• Chemical name: 17-Demethoxy-17-(2-propenylamino) geldanamycin.
• Also known as: NSC330507, 17-(Allylamino)-17-demethoxygeldanamycin
• CAS number: 75747-14-7
• Molecular formula: C31H43N3O8.
• Purity: >99%
• Concentration: 50-100 nM.
• Form: Lyophilized powder.
• Solubility: DMSO, methanol. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: DMSO, methanol. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Source: Semi-synthetic
• Activity: 17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function and displays anti-tumor effects1-3.
• Alternative names: NSC330507, 17-(Allylamino)-17-demethoxygeldanamycin

Scientific background

17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function.1 Hsp90 regulates the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. 17-AAG induces apoptosis and displays anti-tumor effects in tumor cells. 17-AAG depletes cancer cells of erbB-1, erbB-2, Raf-1, and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways.2,3 It also downregulates vascular endothelial growth factor (VEGF) expression.4 17AAG is currently in phase I clinical trial in several centers worldwide.5-8 Preliminary data obtained from these trials demonstrate that anti-tumor activity is achieved at concentrations below the maximum tolerated dose.9

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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