| Field | Specification |
|---|---|
| Alternative names | 2-Aminoethoxydiphenylborane |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C14H16BNO |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
2-APB is a versatile chemical tool that inhibits IP3 receptors and modulates TRP channel activity. In neuroscience, it is widely used to manipulate intracellular calcium release and study calcium-dependent signaling pathways. 2-APB also inhibits gap junctions composed of connexin26 and connexin32, making it relevant in research on neuronal communication and network synchronization. Its broad activity profile supports its use in studies of neurodevelopment, synaptic plasticity, and neurodegeneration.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302-H315-H317-H318-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
2-APB (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-316)
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2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328.
3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.
