| Field | Specification |
|---|---|
| Alternative names | 22-4′-Pyridinecarbonyl jorunnamycin A |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H30N4O8 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
22-(4'-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.), also known as 22-4′-Pyridinecarbonyl jorunnamycin A. It has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling, and it inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), while downregulating metalloproteinases MMP-2 and MMP-9, hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF). It shows potent anticancer activity against non-small cell lung cancer (NSCLC)[1]. It has the molecular formula C32H30N4O8 and a molecular weight of 598.60 g/mol.
Physical & Chemical Properties
| CAS Number | 1178895-15-2 |
|---|---|
| Molecular Formula | C32H30N4O8 |
| Molecular Weight | 598.60 g/mol |
| SMILES | O=C(C1=C(C2=O)C[C@@]3([H])[C@H](C#N)N4[C@@H](COC(C5=CC=NC=C5)=O)C(C(C(OC)=C(C)C6=O)=O)=C6C[C@@]4([H])[C@@]([H])1N3C)C(OC)=C2C |
| Signaling Pathway | PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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