| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3β,24S)-Cholest-5-ene-3,24-diol |
| Cas No. | |
| Form | White solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml - requires warming up to ~40°C). |
| Source | Synthetic |
| Storage |
24(S)-Hydroxycholesterol is a brain-derived oxysterol and a potent endogenous agonist of liver X receptors (LXRs), which regulate cholesterol homeostasis and inflammatory gene expression in the central nervous system. As a major cholesterol metabolite in the brain, it plays a critical role in maintaining neuronal lipid balance. Elevated levels of 24(S)-hydroxycholesterol in cerebrospinal fluid have been associated with early-stage Alzheimer’s disease and mild cognitive impairment, making it a valuable biomarker for neurodegeneration. Additionally, its neurotoxic effects on neuronal cells underscore its dual role as both a physiological regulator and a potential contributor to disease pathology.
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25 - Avoid contact with skin and eyes
24(S)-Hydroxycholesterol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-384)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Lütjohann D., et al. (1996) Proc. Natl. Acad. Sci. USA. 93(18): 9799-804.
3. Kölsch H., et al. (1999) Brain Res. 818(1): 171-5.
4. Schönknecht P., et al. (2002) Neurosci. Lett. 324(1): 83-5.
5. Leoni V., et al. (2006) Neurosci. Lett. 397(1-2): 83-7.
