| Field | Specification |
|---|---|
| Target | |
| Alternative names | 3'-dUTP |
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite |
| Molecular weight | |
| Molecular formula | C9H15N2O14P3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
3'-Deoxyuridine-5'-triphosphate, also known as 3'-dUTP, is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. It strongly and competitively inhibits the incorporation of UTP into RNA, with a Ki value of 2.0 μM[1]. It has the molecular formula C9H15N2O14P3 and a molecular weight of 468.14 g/mol.
Physical & Chemical Properties
| CAS Number | 69199-40-2 |
|---|---|
| Molecular Formula | C9H15N2O14P3 |
| Molecular Weight | 468.14 g/mol |
| Structure Classification | Others |
| SMILES | O=P(O)(O)OP(OP(OC[C@@H](O1)C[C@@H](O)[C@@H]1N2C(NC(C=C2)=O)=O)(O)=O)(O)=O |
| Target | RNA Polymerase |
| Signaling Pathway | Cell Cycle/DNA Damage; Metabolic Enzyme/Protease |
| Initial Source | Endogenous metabolite |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is made from cordycepin in good yield. It competitively and strongly inhibits the incorporation of UTP into RNA by RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in molecular-level studies of the relationship between template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, as it has no effect on poly (rA) synthesis[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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