| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C14H17ClN2O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) serves as a building block and synthetic intermediate, and can be used as a precursor for receptor tyrosine kinase (RTK) inhibitors, dual RTK/histone deacetylase (HDAC) inhibitors, and other anticancer agents. It can also be used to synthesize EGFR inhibitors, such as Erlotinib, that possess antiproliferative activity[1][2]. It is supplied as a white to yellow solid (C14H17ClN2O4, MW 312.75) at 99.55% purity.
Physical & Chemical Properties
| CAS Number | 183322-18-1 |
|---|---|
| Molecular Formula | C14H17ClN2O4 |
| Molecular Weight | 312.75 g/mol |
| Purity | 99.55% |
| Appearance | Solid |
| Color | White to yellow |
| SMILES | ClC1=NC=NC2=C1C=C(OCCOC)C(OCCOC)=C2 |
| Solubility | In Vitro: DMSO: 50 mg/mL (159.87 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Zhang G, et al. Isolation of highly pure erlotinib hydrochloride by recrystallization after nucleophilic substitution of an impurity with piperazine[J]. Research on Chemical Intermediates, 2013, 39(6): 2303-2309.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (159.87 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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