| Field | Specification |
|---|---|
| Alternative names | 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U-18496; NSC-102816; 5-AzaC |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C8H12N4O5 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in 25 mg/ml DMSO or 12 mg/ml Water |
| SMILES | |
| InChIKey | |
| Form | White Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
5-Azacytidine is a DNA methyltransferase inhibitor that incorporates into DNA and forms covalent adducts with DNMT1, leading to enzyme depletion and global DNA demethylation. This reactivates silenced genes and alters epigenetic landscapes. In neurodegenerative disease research, 5-Azacytidine is used to study the role of epigenetic regulation in neuronal differentiation, plasticity, and disease progression. It has also been shown to enhance the efficiency of stem cell reprogramming and promote differentiation into neuronal lineages, making it a valuable tool in regenerative neuroscience and epigenetic therapy development.
Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
- H302- Harmful if swallowed
- H350 – May cause cancer
Precautionary Statements:
- P201 – Obtain special instructions before use.
- P308 + P313 – If exposed or concerned: Get medical advice/attention
5-Azacytidine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-345)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55.
3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.
