| Field | Specification |
|---|---|
| Alternative names | 5'-O-β-D-galactosyl-5-fluorouridine |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C15H21FN2O11 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
5-Fluorouridine 5'-O-β-D-galactopyranoside, also known as 5'-O-β-D-galactosyl-5-fluorouridine, is a 5-fluorouridine proagent. It can be converted by the enzyme β-D-galactosidase into the potent antineoplastic agent 5-fluorouridine[1]. It has the molecular formula C15H21FN2O11 and a molecular weight of 424.33 g/mol.
Physical & Chemical Properties
| CAS Number | 149965-92-4 |
|---|---|
| Molecular Formula | C15H21FN2O11 |
| Molecular Weight | 424.33 g/mol |
| SMILES | O[C@H]1[C@@](N2C(NC(C(F)=C2)=O)=O)([H])O[C@@H]([C@H]1O)CO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3O)O)O)CO |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Across a variety of tumor cell lines in vitro, the IC50 ratio of 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) to 5-Fluorouridine ranged from 500:1-1000:1[1].
In Vivo
In Balb/c mice, 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is more than 100x less toxic to bone marrow cells than 5-Fluorouridine[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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