5-HT2A receptor agonist-3

SKU:BHB21901778
Overview
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5-HT2A receptor agonist-3 (CAS 1391499-52-7) is an agonist supplied as a solid. Reported to act on Human 5-HT 2A Receptor, Human 5-HT 2C Receptor. Relevant to GPCR/G Protein and Neuronal Signaling research. Molecular formula C21H26BrNO3, molecular weight 420.34 g/mol.
Purity 98.53%
CAS Number 1391499-52-7
Molecular Weight 420.34 g/mol
Form Solid
Target Human 5-HT 2A Receptor +1 more
Storage 4°C as supplied; in solvent -80°C
Options selector
Catalog no. Size
HY-153912-1MG 1 mg
HY-153912-5MG 5 mg
HY-153912-10MG 10 mg
HY-153912-50MG 50 mg
Available Options

Select the variant that best fits your experiment. Availability and lead time may vary by option.

  • Options: Size: 1 mg, 5 mg, 10 mg, 50 mg
  • Lead time: varies by selected option.
  • Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light).
  • Shipping: Room temperature in continental US; may vary elsewhere.
  • Upon receipt: refrigerate at 4°C as soon as possible.
Field Specification
Target Human 5-HT 2A Receptor, Human 5-HT 2C Receptor
CAS no. 1391499-52-7
Applications
  • Functional Assay (In Vitro)
Molecular weight 420.34
Molecular formula C21H26BrNO3
Purity 98.53%
SMILES COC1=C([C@H]2N[C@@H](CCC2)CC3=C(C=C(C(OC)=C3)Br)OC)C=CC=C1
Form Solid
Storage 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light).
Shipping Room temperature in continental US; may vary elsewhere.
Catalog no. (Mfr.) HY-153912
Main SKU BHB21901778
Agonists

Compound Overview

5-HT2A receptor agonist-3 ((S,S)-9b) is an agonist of the 5-HT2A receptor, with a Ki of 2.5 nM for the human 5-HT2A receptor, and it shows 124-fold selectivity for 5-HT2A over the structurally similar 5-HT2C receptor[1]. It is supplied as an off-white to light yellow solid (C21H26BrNO3, MW 420.34) at 98.53% purity.

Physical & Chemical Properties

CAS Number 1391499-52-7
Molecular Formula C21H26BrNO3
Molecular Weight 420.34 g/mol
Purity 98.53%
Appearance Solid
Color Off-white to light yellow
SMILES COC1=C([C@H]2N[C@@H](CCC2)CC3=C(C=C(C(OC)=C3)Br)OC)C=CC=C1
Target Human 5-HT 2A Receptor, Human 5-HT 2C Receptor
Signaling Pathway GPCR/G Protein; Neuronal Signaling
Storage 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light).
Shipping Room temperature in continental US; may vary elsewhere.

Biological Activity

Activity & Target

Human 5-HT2A Receptor

2.5 nM (Ki)

Human 5-HT2C Receptor

310 nM (Ki)

Literature Cited

Sources cited in this description. Peer-reviewed publications that used this product are listed under References.

[1]. Juncosa JI Jr, et al. Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. ACS Chem Neurosci. 2013;4(1):96-109.

Safety

For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.

Q.Why is there no price on some sizes?
A.Availability and lead time for those sizes are confirmed on inquiry. Send us the size you need and we will come back with price and lead time.
Q.Can this be used in humans or for diagnostics?
A.No. This product is supplied For Research Use Only. It is not for diagnostic or therapeutic procedures and not for human or veterinary use.

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