| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Leguminosae Lupinus perennis L.; Plant — Compositae |
| Molecular weight | |
| Molecular formula | C22H24O9 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
5'-Methoxynobiletin is a potent, orally active antinociceptive and anti-inflammatory agent. It is a polymethoxyflavone that can be isolated from A. conyzoides[1][2]. It is supplied as a white to light yellow solid (C22H24O9, MW 432.42) at 99.73% purity.
Physical & Chemical Properties
| CAS Number | 6965-36-2 |
|---|---|
| Molecular Formula | C22H24O9 |
| Molecular Weight | 432.42 g/mol |
| Purity | 99.73% |
| Appearance | Solid |
| Color | White to light yellow |
| Structure Classification | Flavonoids Flavones |
| SMILES | O=C1C=C(C2=CC(OC)=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13 |
| Signaling Pathway | Anti-infection |
| Initial Source | Plant — Leguminosae Lupinus perennis L.; Plant — Compositae |
| Solubility | In Vitro: DMSO: 62.5 mg/mL (144.54 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 62.5 mg/mL (144.54 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vivo
5'-Methoxynobiletin (5 mg/kg, IP) significantly lowers leukocyte counts, neutrophil influx, and protein concentration in the exudate, and also reduces levels of several pro-inflammatory mediators[2]. 5'-Methoxynobiletin (100 mg/kg, Orally, once) shows anti-nociceptive and anti-inflammatory activity[2]. In rats, 5'-Methoxynobiletin (10 mg/kg (IV), 50 mg/kg (oral), once) showed low oral bioavailability of around 8-11%[2].
| Animal Model | Swiss mice (female)[2] |
|---|---|
| Dosage | 100 mg/kg |
| Administration | Orally |
| Result | Significantly reduced both phases of formalin-induced nocifensive behavior after 15, 30 and 60 min of oral administration, when compared to control groups. In the neurogenic phase, inhibitions of 43±3%, 68±6% and 53±5% of the nociceptive response were observed, while for the infammatory phase inhibitions were 70±8%, 91±3% and 85±3% after 15, 30 and 60 min of the oral administration of 5'-Methoxynobiletin, respectively. |
| Animal Model | Wistar rats (male)[2] |
|---|---|
| Dosage | 10 mg/kg (IV), 50 mg/kg (oral) |
| Administration | IV, oral, once (Pharmacokinetic Analysis) |
| Result | Pharmacokinetic Parameters of 5'-Methoxynobiletin in male Wistar rats[1]. IV (10 mg/kg) IG (50 mg/kg) λ (h-1) 0.55±0.03 0.29±0.2 Tmax (h) 2.71±0.49 Cmax (mg/L) 0.62±0.21 AUC0-∞ (mg·h/L) 8.19±4.1 3.65±0.8 t1/2 elimination (h) 1.26±0.1 2.31±0.9 CL (L/h.kg) 1.22±0.26 13.68±0.29 Vd, ss (L/kg) 2.24±0.32 47.46±10.10 F (%) 8.67 |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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