| Field | Specification |
|---|---|
| Alternative names | 5'-O-DMT-N2-isobutyrylguanosine |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C35H37N5O8 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
5'-O-DMT-ibu-rG (5'-O-DMT-N2-isobutyrylguanosine) is a chemically modified guanosine derivative that can serve as a novel DNA-binding molecule for developing effective, selective anti-cancer agents. It is supplied as a white to off-white solid (C35H37N5O8, MW 655.70) at 95.39% purity.
Physical & Chemical Properties
| CAS Number | 81246-83-5 |
|---|---|
| Molecular Formula | C35H37N5O8 |
| Molecular Weight | 655.70 g/mol |
| Purity | 95.39% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(NC(C(C)C)=O)NC3=O)O[C@@H]1COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6 |
| Signaling Pathway | Cell Cycle/DNA Damage |
| Solubility | In Vitro: DMSO: 175 mg/mL (266.89 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 175 mg/mL (266.89 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
5'-O-DMT-ibu-rG is a phosphoramidite precursor or protected nucleoside monomer that can be used for solid-phase oligonucleotide synthesis (such as siRNA, antisense oligonucleotides).
Data provided by the manufacturer.
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