| Field | Specification |
|---|---|
| Alternative names | 5-Octyl 2-oxopentanedioate |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C13H22O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
5-Octyl-α-ketoglutarate, also known as 5-Octyl 2-oxopentanedioate, is a cell-permeable substrate for lysine demethylase. It is involved in protein demethylation, inhibits proliferation of wtCRBN-expressing cells, and enhances Lenalidomide-induced sensitivity while inhibiting myeloma (MM) drug resistance in cells. In MM cells undergoing glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1]. It has a molecular formula of C13H22O5 and a molecular weight of 258.31 g/mol.
Physical & Chemical Properties
| CAS Number | 1616344-00-3 |
|---|---|
| Molecular Formula | C13H22O5 |
| Molecular Weight | 258.31 g/mol |
| SMILES | O=C(C(CCC(OCCCCCCCC)=O)=O)O |
| Signaling Pathway | Metabolic Enzyme/Protease; Epigenetics |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Chirackal S, et al. Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide[J]. Blood, 2019, 134: 4410.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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