| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C46H56N7O9P |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
5'-ODMT cEt G Phosphoramidite (Amidite) is a potent nucleic acid analog with excellent safety and antisense activity[1][2]. It is supplied as a white to off-white solid (C46H56N7O9P, MW 881.95) at 99.88% purity.
Physical & Chemical Properties
| CAS Number | 945628-66-0 |
|---|---|
| Molecular Formula | C46H56N7O9P |
| Molecular Weight | 881.95 g/mol |
| Purity | 99.88% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C3=C(C(N=C(N3)NC(C(C)C)=O)=O)N=C2)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC |
| Signaling Pathway | Cell Cycle/DNA Damage |
| Solubility | In Vitro: DMSO: 100 mg/mL (113.39 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, stored under nitrogen, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (113.39 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); stored under nitrogen, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
5'-ODMT cEt G Phosphoramidite Amidite improves RNA-binding ability, influences the construction of antisense oligonucleotides (ASOs) and lowers ASO toxicity, through alteration of nucleotides conformation and 5'-alkyl DNA modification[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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