| Field | Specification |
|---|---|
| Alternative names | Indolo[3,2-b]carbazole-6-carbaldehyde, FICZ |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C19H12N2O |
| Purity | |
| Bioactivity | Ligand |
| Activity | |
| Solubility | Soluble in DMSO (10 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | Yellow solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
6-Formylindolo(3,2-b)carbazole (FICZ) is a high-affinity endogenous ligand for the aryl hydrocarbon receptor (AhR), derived from tryptophan metabolism. FICZ rapidly induces cytochrome P450 enzymes, particularly CYP1A1, at picomolar concentrations, highlighting its potency in modulating gene expression. In neuroscience, FICZ is gaining attention for its role in regulating neuroimmune interactions and oxidative stress via AhR signaling. These pathways are increasingly implicated in neurodegenerative diseases, including multiple sclerosis and Alzheimer’s disease. FICZ’s ability to influence neuroinflammation and cellular detoxification positions it as a promising molecule for studying environmental and metabolic contributions to brain health.
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25 - Avoid contact with skin and eyes
6-Formylindolo[3,2-b]carbazole (FICZ) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-383)
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855.
3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.
