6-Formylindolo[3,2-b]carbazole (FICZ)

6-Formylindolo(3,2-b)carbazole (FICZ) is a high-affinity endogenous ligand for the aryl hydrocarbon receptor (AhR), derived from tryptophan metabolism. FICZ rapidly induces cytochrome P450 enzymes, particularly CYP1A1, at picomolar concentrations, highlighting its potency in modulating gene expression. In neuroscience, FICZ is gaining attention for its role in regulating neuroimmune interactions and oxidative stress via AhR signaling. These pathways are increasingly implicated in neurodegenerative diseases, including multiple sclerosis and Alzheimer’s disease. FICZ’s ability to influence neuroinflammation and cellular detoxification positions it as a promising molecule for studying environmental and metabolic contributions to brain health.

Classification: Caution. Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S24/25 - Avoid contact with skin and eyes

6-Formylindolo[3,2-b]carbazole (FICZ) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-383)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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