| Field | Specification |
|---|---|
| Alternative names | N6-Methyl-ATP |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C11H18N5O13P3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
6-Me-ATP, also known as N6-Methyl-ATP, is an N6-modified ATP derivative. It exhibits excellent binding affinity for GSK3 and serves as the phosphate group donor for GSK3β-catalyzed phosphorylation of its substrate peptides, making it applicable to Alzheimer's disease research[1]. It has the molecular formula C11H18N5O13P3 and a molecular weight of 521.21 g/mol.
Physical & Chemical Properties
| CAS Number | 3130-39-0 |
|---|---|
| Molecular Formula | C11H18N5O13P3 |
| Molecular Weight | 521.21 g/mol |
| SMILES | CNC1=C2N=CN([C@@H]3O[C@H](COP(O)(OP(OP(O)(O)=O)(O)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 |
| Signaling Pathway | PI3K/Akt/mTOR; Stem Cell/Wnt |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
6-Me-ATP (10-200 μM; 20 min-2 h) binds 18 distinct human kinases, including GSK3α and GSK3β, in HEK293T cell lysate; GSK3α shows binding affinity for 6-Me-ATP similar to that for native ATP[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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