| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Myrtaceae Melaleuca citrina (Curtis) Dum.Cours.; Plant — Ericaceae Kalmia latifolia L. |
| Molecular weight | |
| Molecular formula | C18H16O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
8-Demethyleucalyptin is a natural flavonoid. It has the molecular formula C18H16O5 and a molecular weight of 312.32 g/mol.
Physical & Chemical Properties
| CAS Number | 5689-38-3 |
|---|---|
| Molecular Formula | C18H16O5 |
| Molecular Weight | 312.32 g/mol |
| Structure Classification | Flavonoids Other Flavonoids |
| SMILES | O=C1C=C(C2=CC=C(OC)C=C2)OC3=C1C(O)=C(C)C(OC)=C3 |
| Initial Source | Plant — Myrtaceae Melaleuca citrina (Curtis) Dum.Cours.; Plant — Ericaceae Kalmia latifolia L. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Against MSSA ATCC 25923 and MRSA ATCC 33591, 8-Demethyleucalyptin shows bacteriostatic activity, with MIC values of 31.25 μg/mL and 62.5 μg/mL, respectively[1]. At 15.625-31.25 μg/mL for 48 h, 8-Demethyleucalyptin inhibits biofilm formation of MRSA and MSSA, with inhibition rates of 31.6% and 37.1%[1]. Staphyloxanthin biosynthesis in MRSA and MSSA is weakly inhibited by 8-Demethyleucalyptin (15.625-31.25 μg/mL; 48 h), with inhibition rates of 14.2% and 22.2%, and acid tolerance is reduced[1]. At 31.25-62.5 μg/mL for 18 h, 8-Demethyleucalyptin disrupts the integrity of the cell membrane and wall in MSSA and MRSA[1]. Over 48-72 h, 8-Demethyleucalyptin inhibits the viability of HCT116 and MRC-5 cells (IC50 = 6.4 and 7.0 μM, respectively), while the IC50 for Jurkat cells is >100 μM[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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