| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C3013C4H66O4 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
9-PAHSA-13C4 is a 13C-labeled analog of 9-PAHSA, an orally active endogenous GPR120 agonist (EC50 18 μM) that blocks the NF-κB pathway to significantly inhibit LPS-induced inflammatory responses. It also promotes adipocyte browning, increases glucose uptake, and lowers lipid accumulation while improving mitochondrial function and the survival rate of steatotic hepatocytes. In the prefrontal cortex of diabetic mice, it modulates REST and BDNF expression and prevents spatial working memory deficits and abnormal social behaviors, though it does not directly regulate insulin secretion or improve systemic insulin sensitivity. These anti-inflammatory, metabolic regulatory, and neuroprotective properties support its use in research on diabetes-related cognitive impairment, obesity, and non-alcoholic fatty liver disease[1][2][3][4]. It is a colorless to light yellow liquid (C3013C4H66O4, MW 542.86) at 99.9% purity.
Physical & Chemical Properties
| CAS Number | 2748638-71-1 |
|---|---|
| Molecular Formula | C3013C4H66O4 |
| Molecular Weight | 542.86 g/mol |
| Purity | 99.9% |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| Unlabeled CAS | 1481636-31-0 |
| SMILES | CCCCCCCCCCCC[13CH2][13CH2][13CH2][13C](OC(CCCCCCCCC)CCCCCCCC(O)=O)=O |
| Signaling Pathway | Neuronal Signaling; GPCR/G Protein; NF-κB |
| Storage | Solution, -20°C, 2 years. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[4]. Wang Y M, et al. 9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide/NF-kappa B pathway[J]. Biochemical and biophysical research communications, 2018, 506(1): 153-160.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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