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Compound Overview
9(Z),11(E),13(E)-Octadecatrienoic Acid (CAS 506-23-0) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 506-23-0 |
|---|---|
| Molecular Formula | C18H30O2 |
| Molecular Weight | 278.44 g/mol |
| SMILES | CCCCC=CC=CC=C/CCCCCCCC(O)=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
9(Z),11(E),13(E)-Octadecatrienoic Acid (alpha-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. alpha-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, alpha-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARgamma. In DLD-1 cells supplemented with alpha-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 uM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 uM for different isoforms of the enzymes.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
Effective dose 50 (ED50）refers to the dose of a drug that produces a specific effect in 50% of the population that has been administered that dose.
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