| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine.
- Also known as: N-Cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine
- CAS number: 1125758-85-1
- Molecular formula: C19H17N5.
- Purity: >99%
- Concentration: 1-100 nM.
- Form: Lyophilized Powder
- Solubility: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X7 receptors
- Source: Synthetic
- Activity: A-804598 is a potent and selective, competitive and high-affinity antagonist of the purinergic P2X7 receptor, with IC50 values of around 10 nM for mouse, rat, and human receptors1-3.
- Alternative names: N-Cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine
Scientific background
A-804598 is a potent, competitive, and selective antagonist of the P2X7 receptor. It displays IC50 values of 10 nM, 9 nM and 11 nM for rat, mouse and human P2RX7, respectively1.P2X receptors are a family of ligand-gated cation channels activated by the binding of extracellular ATP. To date, seven members of this family have been identified and shown to function as either homomeric or heteromeric combinations2. P2X7 receptors mediate the release of proinflammatory cytokines2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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