| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 9-(dimethylamino)-3-(4-methylphenyl)pyrido[2,3]thieno[2,4-d]pyrimidin-4-one.
- Also known as: CHEMBL223869, GTPL6355, SCHEMBL6102967, BDBM50177062
- CAS number: 869802-73-3
- Molecular formula: C18H16N4OS.
- Purity: >99%
- Concentration: 1 nM - 1 µM.
- Form: Lyophilized Powder
- Solubility: Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: mGluR1 receptor
- Source: Synthetic
- Activity: A-850002 inhibits mGluR1 in rat primary cerebellar granule neurons with an IC50 of 27 nM1 and human mGluR1 expressed in 1321N1 cells with an IC50 of 43 nM2.
- Alternative names: CHEMBL223869, GTPL6355, SCHEMBL6102967, BDBM50177062
Scientific background
A-850002 is a synthetic, selective and potent antagonist of mGluR1 receptors. It inhibits mGluR1 receptors in rat primary cerebellar granule neurons with an IC50 value of 27 nM in calcium mobilization assays and human mGluR1 receptors expressed in 1321N1 type cells with an IC50 of 43 nM1,2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells, neural stem cells and the formation of the hippocampus3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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