| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1-(3-methylpyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide.
- CAS number: 1072921-02-8
- Molecular formula: C19H18F3N3O3S.
- Purity: >98% (HPLC)
- Concentration: 0.5 nM - 50 µM.
- Form: Lyophilized powder.
- Solubility: DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
- Reconstitution: DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPV1 channels
- Source: Synthetic
- Activity: A-889425 blocks TRPV1 channels with an IC50 of 335 nM (rat) and 34 nM (human)1.
Scientific background
TRPV1 (transient receptor potential vanilloid family type 1) channels are activated and/or modulated by noxious heat, capsaicin, protons and other endogenous agents released following tissue injury.A-889425 is a selective and competitive TRPV1 channel blocker with an IC50 of 335 nM to displace capsaicin at rat receptors, and has good penetration into the CNS1. In the somatic sensory system, receptor-selective TRPV1 antagonists, such as A-889425, attenuate mechanical hyperalgesia in models of inflammatory, osteoarthritic, and neuropathic pain2. Administration of A-889425 inhibited mechanically evoked activity of wide dynamic range (WDR) neurons in the rat spinal dorsal horn under conditions of peripheral inflammation but not in uninjured rats1.In addition to actions on the nociceptive system, several TRPV1 blockers like A-889425 have been reported to affect thermoregulation by transiently raising core body temperature following systemic administration in both animals and humans3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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