| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C50H93N3O2 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
A18-Iso5-2DC18 is a cyclic lipidoid that partially activates STING. It promotes mRNA protein expression and induces a strong immune response, and it can be used in melanoma research[1]. It is supplied as a yellow to brown liquid (C50H93N3O2, MW 768.29) at 95.0% purity.
Physical & Chemical Properties
| CAS Number | 2412492-09-0 |
|---|---|
| Molecular Formula | C50H93N3O2 |
| Molecular Weight | 768.29 g/mol |
| Purity | 95.0% |
| Appearance | Liquid |
| Color | Yellow to brown |
| Density | 0.94 g/cm3 |
| SMILES | CCCCCCCC/C=C\CCCCCCCC1(N(C(N=C1)C(OCC)=O)CCCN2C(CCCC2)CC)CCCCCCC/C=C\CCCCCCCC |
| Signaling Pathway | Metabolic Enzyme/Protease; Immunology/Inflammation |
| Solubility | In Vitro: DMSO: 100 mg/mL (130.16 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Miao L, et al. Ionizable lipidoids and their uses. WO2020047399A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (130.16 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | 2.5 mg/mL (3.25 mM); suspension; requires sonication |
| How to prepare | Gives a suspension at 2.5 mg/mL. The suspension is suitable for oral and intraperitoneal dosing. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 2
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (3.25 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
LNPs containing A18-Iso5-2DC18 lower the number of OVA peptide-pulsed splenocytes[1], and raise IFN-t positive secretion in splenocytes[1].
In Vivo
In the B16F10-OVA mouse melanoma model, LNPs containing A18-Iso5-2DC18 significantly suppress tumor growth and extend the survival of mice[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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