| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 5-(Methylamino)-2-({(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)-2-propanyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid, A23187, Calcimycin |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| Source | Synthetic |
| Storage |
A23187 is a divalent cation ionophore that facilitates the transport of calcium and other divalent cations across biological membranes. It is widely used in neuroscience research to artificially elevate intracellular calcium levels, enabling the study of calcium-dependent signaling pathways, neurotransmitter release, and apoptosis. A23187 has also been shown to modulate neuronal survival and death, depending on cellular context, making it a valuable tool for investigating calcium-mediated neurodegenerative mechanisms.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
A23187 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-227)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. http://a23187.4mg.com
