AA 29504

Product details

• Chemical name: Ethyl N-[2-amino-4-[(2,4,6-trimethylphenyl)methylamino]phenyl]carbamate.
• CAS number: 945828-50-2
• Molecular formula: C19H25N3O2.
• Purity: >98%
• Concentration: 1-100 µM.
• Form: Lyophilized powder.
• Solubility: Soluble in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).
• Reconstitution: Soluble in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: GABA(A) receptors
• Source: Synthetic
• Activity: AA 29504 is a positive allosteric modulator of GABA(A) receptors, reducing the EC50 of GABA and gaboxadol at the α4β3δ and α1β3γ2S receptors in Xenopus oocytes at over 1 µM. AA 29504, a retigabine analogue, also exhibits some agonistic activity on KCNQ channels (EC50=9.6-13.5 µM)1.

Scientific background

AA 29504, a close analogue of retigabine (KCNQ channel opener), acts as a positive allosteric modulator of GABA(A) receptors. A study in adult rats shows that systemic administration of AA 29504 produces anxiolytic effects and reduces motor coordination1.AA 29504 decreases the EC50 value of GABA at the GABA (A) receptors in Xenopus oocytes at over 1 µM. The compound also exhibits agonistic activity on KCNQ channels and demonstrates EC50 values of 9.6-13.5 µM1.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. These receptors mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system (CNS). They play an important role in inhibiting cell excitation in the CNS. The GABA(A) receptor is considered to be a major target of antiseizure drugs2,3.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).