| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride.
- Also known as: N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride, GSK314181A
- CAS number: 1101868-22-7
- Molecular formula: C23H33Cl2N3O (C23H32ClN3O · HCl).
- Purity: >99%
- Concentration: 1-100 nM.
- Form: Lyophilized Powder
- Solubility: Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X7 receptors
- Source: Synthetic
- Activity: AACBA hydrochloride is a potent and selective antagonist of P2X7 receptors, shown to inhibit human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively. Active in vivo on acute models of pain and inflammation1.
- Alternative names: N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride, GSK314181A
Scientific background
AACBA hydrochloride is a potent and selective antagonist of P2X7 receptors. It inhibits human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively1.AACBA reduces interleukin-6 release in a dose-dependent manner and prevents or reverses carrageenan-induced paw edema and mechanical hypersensitivity in acute in vivo models of pain and inflammation1.P2X receptors are a family of ion channels gated by ATP, a ubiquitous energy donor and receptor ligand in living cells. P2X receptors are widely expressed in neuronal, muscular, epithelial and immune cells and play a pivotal role in models of various pain conditions. P2X7 receptor mediates the release of proinflammatory cytokines known to have roles in inflammatory/immune conditions and pain1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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