| Field | Specification |
|---|---|
| Target | |
| Alternative names | Aggrecan core protein|Cartilage-specific proteoglycan core protein (CSPCP)|Chondroitin sulfate proteoglycan core protein 1 (Chondroitin sulfate proteoglycan 1)|Aggrecan core protein 2|ACAN|AGC1|CSPG1|MSK16 |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | aggrecan |
| Conjugate | |
| Molecular weight | |
| Purity | |
| Purification | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Scientific Background
Aggrecan(ACAN), also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family(also including versican, brevican and neurocan). It is a major component of extracellular matrix of cartilagenous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site(PMID: 7852317; 9337874).
Product Overview
This polyclonal antibody, raised in Rabbit, recognizes ACAN. It is validated for ELISA, Western Blot, Immunohistochemistry.
Validated Applications
| Applications | ELISA, Western Blot, Immunohistochemistry |
|---|---|
| WB | 1:500-1:1000 |
| IHC | 1:20-1:200 |
Optimal dilutions should be determined by the end user for each application and sample type.
Immunogen
aggrecan
Specifications
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Immunogen | aggrecan |
| Purification | Immunogen Affinity Purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Form | Liquid |
| Target MW | 70 kDa, 250-260 kDa |
| UniProt # | P16112 |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Alternative Names | Aggrecan core protein|Cartilage-specific proteoglycan core protein (CSPCP)|Chondroitin sulfate proteoglycan core protein 1 (Chondroitin sulfate proteoglycan 1)|Aggrecan core protein 2|ACAN|AGC1|CSPG1|MSK16 |
Reactivity Notes
Validated reactivity: Human, Mouse, Rat. For other species, epitope conservation may allow cross-reactivity; confirm with appropriate controls.
Safety & Handling
This product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. The formulation contains sodium azide; handle with standard laboratory precautions.
Related Products
Explore related antibodies and reagents for ACAN research from Fine Test, or contact us for alternative formats.
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