| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C20H25BrN4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AChE/Aβ-IN-1 is a potent, orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 86 nM, and an antagonist of the NMDA receptor (GluN1-1b/GluN2B subunit combination) with an IC50 of 3.876 μM. It also inhibits Aβ aggregation and shows good blood-brain barrier permeability and neuroprotection, improving cognitive and spatial memory impairment in a rat model[1]. It has the molecular formula C20H25BrN4 and a molecular weight of 401.34 g/mol.
Physical & Chemical Properties
| Molecular Formula | C20H25BrN4 |
|---|---|
| Molecular Weight | 401.34 g/mol |
| SMILES | BrC1=CC=C(C=C1)CN2C=C(N=N2)CNC34CC(C5)CC(C4)CC5C3 |
| Signaling Pathway | Membrane Transporter/Ion Channel; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 86 nM (AChE), 3.876 μM (NMDA receptor, GluN1-1b/GluN2B subunit)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
AChE/Aβ-IN-1 (5-20 μM; 48 h) inhibits the aggregation of Aβ1-42 (10 μM)[1].
In Vivo
In rat models, AChE/Aβ-IN-1, given po at 10 mg/kg/d for 7 days, inhibits Aβ1-42-induced memory deficits and decreases the time spent in the platform zone during the Morris water maze[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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