| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H19BrN2O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AChE-IN-29, a 3-OH pyrrolidine derivative, is a cholinesterase (ChE) inhibitor. It inhibits hAChE, eeAChE, and eqBChE with IC50 values of 0.25 μM, 0.23 μM, and 0.72 μM, respectively, and can be used in Alzheimer's disease research[1]. It has a molecular formula of C18H19BrN2O2 and a molecular weight of 375.26 g/mol.
Physical & Chemical Properties
| CAS Number | 3041113-91-8 |
|---|---|
| Molecular Formula | C18H19BrN2O2 |
| Molecular Weight | 375.26 g/mol |
| SMILES | O=C(C1=CC=C(C=C1)Br)NC2=CC=CC=C2CN3CC[C@@H](C3)O |
| Signaling Pathway | Immunology/Inflammation; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 0.25 μM (hAChE); 0.23 μM (eeAChE); eqBChE (0.72 μM); 24.12 μM (in DPPH assay)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
AChE-IN-29 (VA10) can effectively inhibit AChE, BChE and Aβ1-42[1]. AChE-IN-29 inhibits cholinesterases, with IC50 values of 0.25 μM for hAChE, 0.23 μM for eeAChE and 0.72 μM for eqBChE[1]. In the DPPH assay, AChE-IN-29 shows significant antioxidant activity with an IC50 value of 24.12 μM[1]. At 5 μM, 10 μM, 20 μM, AChE-IN-29 can inhibit hAChE-induced Aβ1-42 aggregation and self-induced Aβ1-42 aggregation[1].
Cell Viability Assay[1]
| Cell Line | SH-SY5Y cells |
|---|---|
| Concentration | 5, 10, and 20 μM |
| Incubation Time | 72 h |
| Result | Reduced the Aβ1-42 aggregation and showed no toxic effects on tested cell line (SH-SY5Y). |
In Vivo
AChE-IN-29 (VA10) (p.o.; 2.5, 5, and 10 mg/kg) improves memory and cognitive dysfunctions through AChE activity inhibition[1]. AChE-IN-29 (p.o.; 10 mg/kg) restores cell density in the hippocampus region[1].
| Animal Model | Male Wistar rats (200 ± 15 g)[1] |
|---|---|
| Dosage | 2.5, 5, and 10 mg/kg |
| Administration | p.o.; once a day for seven days |
| Result | Improved cognition and memory in the scopolamine-induced cholinergic deficit. Restoresd the neuronal cells and can inhibit neuronal toxicity in AD conditions. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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