| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C29H34N2O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AcrB-IN-4 is an inhibitor of the AcrB efflux pump, able to potentiate the effect of antibiotics. It inhibits efflux of Nile Red, a known AcrB substrate, without disrupting the bacterial outer membrane or showing toxicity in a nematode model[1]. It has a molecular formula of C29H34N2O4S and a molecular weight of 506.66 g/mol.
Physical & Chemical Properties
| CAS Number | 2890177-95-2 |
|---|---|
| Molecular Formula | C29H34N2O4S |
| Molecular Weight | 506.66 g/mol |
| SMILES | O=C(N1CCOCC1)C2=CC3=C(C4=C2CCC(C)(C)O4)C=CC=C3OCCCSC5=CC=C(C=C5)N |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
At 8-128 μg/mL, Efflux pump-IN-4 displays outstanding synergistic antibacterial activity with at least one of the antibiotics (ERY, LEV, and MIN). Efflux pump-IN-4 is synergistic with MIN, and at 8 μg/mL it lowers the MIC value of LEV by 4-fold[1]. Efflux pump-IN-4 (50 μM, 100 μM) strongly inhibits Nile Red efflux, already at the lowest concentration of 50 μM[1]. Efflux pump-IN-4 (4-256 μg/mL) causes no hemolysis of mouse red blood cells[1].
In Vivo
Efflux pump-IN-4 (128 μg/mL; 72 h) shows no significant in vivo toxicity toward Caenorhabditis elegans[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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