| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C43H47N3O10 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Activated EG3 Tail can be used in the synthesis of exon-jumping oligomer conjugates[1]. It is supplied as a white to off-white solid (C43H47N3O10, MW 765.85) at 99.31% purity.
Physical & Chemical Properties
| CAS Number | 1380600-06-5 |
|---|---|
| Molecular Formula | C43H47N3O10 |
| Molecular Weight | 765.85 g/mol |
| Purity | 99.31% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C([C@]1([H])[C@]([C@@]2([H])C[C@]1([H])C=C2)([H])C3=O)N3OC(CCC(OCCOCCOCCOC(N(CC4)CCN4C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O)=O)=O |
| Solubility | In Vitro: DMSO: 100 mg/mL (130.57 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Passini MA, et al. Exon skipping oligomer conjugates for muscular dystrophy. World Intellectual Property Organization, WO2018118599 A1. 2018-06-28.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (130.57 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
An oligomer conjugate complementary to the chosen target site in the human dystrophin gene is yielded by Activated EG3 Tail, and exon 51 skipping can be induced with it. Activated EG3 Tail can serve in muscular dystrophy research[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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