| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H28N2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AD186 is a potent, selective agonist of the sigma-1 receptor (S1R), with Ki values of 2.7 nM and 27 nM for S1R and S2R, respectively. It fully reverses the antiallodynic effect of BD-1063[1]. It has a molecular formula of C22H28N2 and a molecular weight of 320.47 g/mol.
Physical & Chemical Properties
| Molecular Formula | C22H28N2 |
|---|---|
| Molecular Weight | 320.47 g/mol |
| SMILES | N1(CCC2=CC=CC=C2)CC3(CCN(CC4=CC=CC=C4)CC3)C1 |
| Target | Sigma 1 Receptor, Sigma 2 Receptor |
| Signaling Pathway | Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
Sigma 1 Receptor 2.7 nM (Ki) |
Sigma 2 Receptor 27 nM (Ki) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
In capsaicin-induced mechanical hypersensitivity in mice, AD186 (2.5-10 mg/kg; s.c.) completely reverses the antiallodynic effect of BD-1063[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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