| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-(4-Benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide |
| Cas No. | |
| Form | White crystalline powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (40 mg/ml); or ethanol (20 mg/ml) |
| Source | Synthetic |
| Storage |
Adiporon is a potent and selective agonist of adiponectin receptors AdipoR1 and AdipoR2, mimicking adiponectin's metabolic effects. It activates AMPK and PPARα signaling pathways, improving insulin sensitivity and reducing oxidative stress. In neurodegenerative disease models, Adiporon has been shown to clear neurofibrillary tangles and rescue tauopathy-associated neuronal defects. Its systemic metabolic benefits, combined with neuroprotective properties, position it as a promising candidate for therapeutic development in Alzheimer's disease and other tauopathies.
Details:
Not a hazardous substance or mixture.
Adiporon (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-635)
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. S Lee and HB Kwak (2014)J. Exerc. Rehabil. 10:54
3. Y Zhang et al. (2015) Am. J. Physiol. Endocrinol. Metab. 309:E275. 4. E.R. McGregor et al. (2025) Comm Biol. 8 : https://www.nature.com/articles/s42003-024-07391-z