| Field | Specification |
|---|---|
| Alternative names | Ro-4 hydrochloride |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C14H18ClIN4O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AF-353 hydrochloride, also known as Ro-4 hydrochloride, is a potent, selective, orally bioavailable antagonist of the P2X3 and P2X2/3 receptors. It has a pIC50 of 8.0 at both human and rat P2X3, and a pIC50 of 7.3 at human P2X2/3[1][2]. It has a molecular formula of C14H18ClIN4O2 and a molecular weight of 436.68 g/mol.
Physical & Chemical Properties
| CAS Number | 927887-18-1 |
|---|---|
| Molecular Formula | C14H18ClIN4O2 |
| Molecular Weight | 436.68 g/mol |
| SMILES | IC1=C(OC)C=C(C(C)C)C(OC2=CN=C(N)N=C2N)=C1.Cl |
| Signaling Pathway | Membrane Transporter/Ion Channel |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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