| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Tyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml) |
| Source | Synthetic |
| Storage |
AG 879 is a selective inhibitor of the tyrosine kinase activity of the nerve growth factor (NGF) receptor TrkA, with additional inhibitory effects on ErbB2 and VEGFR-2. In neuroscience, AG 879 is primarily used to investigate NGF-TrkA signaling, a pathway critical for neuronal survival, differentiation, and axonal growth. Dysregulation of NGF signaling has been implicated in neurodegenerative diseases such as Alzheimer’s and peripheral neuropathies, where impaired neurotrophic support contributes to neuronal loss and synaptic dysfunction.
By inhibiting TrkA, AG 879 enables researchers to dissect the role of NGF in maintaining neuronal integrity and to model conditions of neurotrophin deprivation. Its additional activity against ErbB2 and VEGFR-2 expands its utility in studying neurovascular interactions and glial responses, particularly in the context of neuroinflammation and blood-brain barrier regulation. AG 879 is a valuable tool for exploring therapeutic strategies aimed at modulating neurotrophic signaling and protecting against neurodegeneration.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
AG 879 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-429)
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2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.
